Dystrophinopathy-associated dysfunction of Krebs cycle metabolism
نویسندگان
چکیده
منابع مشابه
The relationship between calcium-phosphorus metabolism, the 'Krebs cycle' and steroid metabolism.
It has been shown in the course of the last few years that the number of factors playing a part in calcium-phosphorus (Ca-P) metabolism is far greater than had been known. It was found that the calcification of bones depends in the first place on the 'citric acid cycle' and on adenosine triphosphate (ATP) (oxidative phosphorylation) (Dickens, 1941; Albaum, Hirshfeld and Sobel, 1952; Dixon and P...
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A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates. Four solvent systems which allowed separation of various combinations of acids are described and the limits of this method of separa...
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To examine the fate of the carbons of acetate and to evaluate the usefulness of labeled acetate in assessing intrahepatic metabolic processes during gluconeogenesis, [2-14C]acetate, [2-14C]ethanol, and [1-14C]ethanol were infused into normal subjects fasted 60 h and given phenyl acetate. Distributions of 14C in the carbons of blood glucose and glutamate from urinary phenylacetylglutamine were d...
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For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle. The exact source of this disturbance remains unclear, because a great many metabolic blocks and bottlenecks can disturb the anaplerotic ...
متن کاملSodium-coupled transporters for Krebs cycle intermediates.
Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate are transferred across plasma membranes of cells by secondary active transporters that couple the downhill movement of sodium to the concentrative uptake of substrate. Several transporters have been identified in isolated membrane vesicles and cells based on their functional properties, suggesting the existence of at ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2018
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddy404